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Effects of osmoprotective eye drops on tear osmolarity in contact lens wearers

      Abstract

      Objective

      To evaluate the impact of osmoprotective eye drops on tear osmolarity and patient comfort, and to compare its efficacy with a commercially available lubricant in contact lens (CL) wearers.

      Design

      Prospective, cross-sectional study.

      Participants

      Forty eyes of 20 first-time CL wearers were included.

      Methods

      Tear osmolarity measurements using TearLab osmolarity system were performed in each eye of subjects at 8 am, and 2, 4, and 8 h after that on the first and second days, and at 12:00 on the third day and eighth days. On the second day and afterward, all eyes were fitted Purevision 2 (Bausch & Lomb) soft CLs. Subjects instilled Optive (Allergan) osmoprotective eye drops into their 1 eye (group 1) and Refresh tears (Allergan) eye drops into their other eyes (group 2) after 2 hours of CL wear on the third day and afterward. Ocular comfort with eye drops was also assessed.

      Results

      There were no significant differences between the tear osmolarity measurements of the groups on the first day. On the second day, osmolarity significantly increased from baseline after 4 h of CL wear (p < 0.05) but returned to baseline after 8 h of CL wear (p > 0.05) in both groups. Tear osmolarity measurements of group 1 were significantly lower than those of group 2 on the third and eighth days (both p < 0.05). The mean comfort scores were significantly higher in group 1.

      Conclusions

      Tear osmolarity increases within the first hours of CL wear, and instillation of osmoprotective eye drops prevents this increment in patients wearing CLs.

      Résumé

      Objet?>

      Évaluer l’effet de gouttes ophtalmiques osmoprotectrices sur l’osmolarité des larmes et sur le confort du patient, et comparer leur efficacité avec celle d’un lubrifiant du commerce chez des porteurs de lentilles cornéennes.

      Nature?>

      Étude transversale prospective.

      Participants?>

      40 yeux de 20 sujets portant des lentilles cornéennes pour la première fois.

      Méthodes?>

      À l’aide du système TearLab, on a mesuré l’osmolarité des larmes de chaque œil des sujets à 8 h ainsi que 2 heures, 4 heures et 8 heures plus tard le premier et le deuxième jour, puis à 12 h le troisième et le huitième jour. Le deuxième jour et les suivants, tous les yeux ont reçu des lentilles souples Purevision 2 (Bausch & Lomb). Le troisième jour et les suivants, après 2 heures de port des lentilles, les sujets se sont instillé des gouttes ophtalmiques osmoprotectrices Optive (Allergan) dans un œil (groupe 1) et des gouttes Refresh Tears (Allergan) dans l’autre œil (groupe 2). On a aussi évalué le confort oculaire avec les gouttes ophtalmiques.

      Résultats?>

      Il n’y avait pas de différence significative entre les mesures de l’osmolarité des larmes des deux groupes le premier jour. Le deuxième jour, l’osmolarité avait significativement augmenté par rapport au niveau de référence après 4 heures de port des lentilles cornéennes (p < 0,05), mais elle avait rebaissé au niveau de référence après 8 heures de port (p > 0,05), dans les deux groupes. Les mesures de l’osmolarité des larmes du groupe 1 étaient significativement plus faibles que celles du groupe 2 le troisième et le huitième jour (p < 0,05 dans les ceux cas). Les scores moyens relatifs au confort étaient significativement plus élevés dans le groupe 1.

      Conclusions?>

      L’osmolarité des larmes augmente pendant les premières heures de port de lentilles cornéennes, et l’instillation de gouttes ophtalmiques osmoprotectrices empêche cette augmentation chez les porteurs de lentilles cornéennes.
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