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Acute myelogenous leukemia presenting with uveitis, optic disc edema, and granuloma annulare: Case report

  • Kevin Shen
    Affiliations
    Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX

    Baylor College of Medicine, Houston, TX

    Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medical College, New York, NY

    Department of Ophthalmology, The University of Texas Medical Branch, Galveston, TX

    Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA

    UT MD Anderson Cancer Center
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  • Stacy V. Smith
    Affiliations
    Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX

    Baylor College of Medicine, Houston, TX

    Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medical College, New York, NY

    Department of Ophthalmology, The University of Texas Medical Branch, Galveston, TX

    Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA

    UT MD Anderson Cancer Center
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  • Andrew G. Lee
    Correspondence
    Correspondence to: Andrew G. Lee, MD
    Affiliations
    Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX

    Baylor College of Medicine, Houston, TX

    Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medical College, New York, NY

    Department of Ophthalmology, The University of Texas Medical Branch, Galveston, TX

    Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA

    UT MD Anderson Cancer Center
    Search for articles by this author
      Although ocular manifestations of the acute leukemias have been reported commonly, the majority of these reports refer to acute lymphoblastic leukemia rather than Acute myelogenous leukemia (AML).
      • Sharma T.
      • Grewal J.
      • Gupta S.
      • Murray P.I.
      Ophthalmic manifestations of acute leukaemias: the ophthalmologist׳s role.
      Uveitis is a rare finding with AML. In cases in which uveitis has been reported as a manifestation of AML, it has been identified most commonly as a sign of relapsing or progressing AML rather than as the initial presenting finding of previously undiagnosed AML.
      • Ayliffe W.
      • Foster C.S.
      • Marcoux P.
      • et al.
      Relapsing acute myeloid leukemia manifesting as hypopyon uveitis.
      • Matano S.
      • Ohta T.
      • Nakamura S.
      • Kanno M.
      • Sugimoto T.
      Leukemic hypopyon in acute myelogenous leukemia.
      • Novakovic P.
      • Kellie S.J.
      • Taylor D.
      Childhood leukaemia: relapse in the anterior segment of the eye.
      • Arbuthnot C.D.
      • Bradbury M.
      • Darbyshire P.J.
      Relapsing acute myeloid leukaemia manifesting as uveitis with hypopyon.
      • Gan N.Y.
      • King L.L.
      • Teoh S.C.
      Ocular masquerade syndrome as a herald of progression of acute myelogenous leukemia.
      We report a patient with AML who presented with uveitis, optic disc edema, and an additional suggestive skin finding of granuloma annulare (GA). To our knowledge, this is only the third reported case of AML initially presenting as uveitis and the first reported case in the English language literature of uveitis, GA, and optic disc edema as presenting findings of AML.
      • Bhadresa G.N.
      Changes in the anterior segment as a presenting feature in leukaemia.
      • Daneshvar H.
      • Hodge W.
      • Gilberg S.
      Acute myelogenous leukaemia in an adult presenting with uveitis.
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