Quality of life of low vision patients: a systematic review and meta-analysis

Published:November 13, 2020DOI:



      Quality of vision plays an important role in everyday living, and low vision (LV) can take a toll on individual's quality of life (QOL). The objective of this paper is to evaluate the impact of LV on QOL and depressive symptoms in LV patients compared with healthy controls.


      Systematic review and meta-analysis.


      Literature was systematically searched to obtain all relevant records. Covidence software was used to conduct the systematic review. Duplicate records were removed, and 2 independent reviewers screened records for relevance. After screening, risk of bias assessment was carried out. Data were extracted and meta-analysis was performed using STATA 15.0. Fixed-effect and random-effect models were computed based on heterogeneity.


      In total, 2870 records were retrieved from database and grey literature searches. Twelve articles (35 341 subjects) were included for quantitative analysis. Overall, the QOL of LV patients was significantly lower compared with healthy individuals. Common QOL questionnaires, including 25-item visual function questionnaire (VFQ-25) (standard mean difference [SMD] = 0.91, confidence interval [CI]: [0.42–1.40]), 36-item short form survey (SMD = 0.53, CI: [0.26–0.80]), VFQ-14 (SMD = 0.58, CI: [0.42–0.74]), and visual function QOL questionnaire (SMD = 0.68, CI: [0.54–0.82]), demonstrated a poor QOL in LV patients compared with healthy controls. Additionally, odds of depressive symptoms were significantly greater (odds ratio = 2.25, CI: [1.58–3.21]) in LV patients compared with controls.


      LV patients demonstrated a poor QOL and higher odds of depressive symptoms compared with healthy controls.


      Comme la qualité de la vision joue un rôle prépondérant dans la vie de tous les jours, une basse vision (BV) peut altérer la qualité de vie (QdV). Le présent article se penche sur l'effet d'une BV sur la QdV et les symptômes de dépression chez des sujets à BV, comparativement à des sujets sains.


      Revue de synthèse systématique et méta-analyse.


      On a procédé à une recherche systématique de la littérature médicale pour obtenir tous les articles pertinents, qui ont été passés en revue par le logiciel Covidence. Les articles en double ont été éliminés, et 2 examinateurs indépendants ont vérifié la pertinence des articles retenus. Par la suite, on a procédé à une évaluation du risque de biais. Une fois les données extraites, on a eu recours au logiciel STATA 15.0 pour réaliser la méta-analyse. Des modèles à effet fixe et à effet aléatoire ont été générés en fonction de l'hétérogénéité.


      Au total, 2870 articles ont été extraits lors des recherches dans les bases de données et la documentation parallèle. Douze articles (35 341 sujets) ont été retenus en vue de l'analyse quantitative. Dans l'ensemble, la QdV des patients à BV était significativement inférieure à celle des sujets sains. Les questionnaires habituels servant à mesurer la QdV – dont le Visual Function Questionnaire en 25 items (VFQ-25; différence moyenne standardisée [DMS] = 0,91; intervalle de confiance [IC]: 0,42–1,40), la version abrégée en 36 items (DMS = 0,53; IC: 0,26–0,80), le VFQ-14 (DMS = 0,58; IC: 0,42–0,74) et le Visual Function QOL Questionnaire (DMS = 0,68; IC : 0,54–0,82) – ont fait ressortir une QdV médiocre chez les patients à BV, comparativement aux sujets sains. Qui plus est, les cotes d'apparition de symptômes dépressifs étaient significativement plus élevées (rapport de cotes = 2,25; IC: 1,58–3,21) chez les patients à BV que chez les sujets sains.


      Les patients à BV affichaient une QdV médiocre et des cotes plus élevées de symptômes dépressifs, comparativement aux sujets sains.
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