Abstract
Objective
To evaluate inflammatory indices of complete blood count (CBC) in patients with Fuchs
uveitis syndrome (FUS), and to compare the results with healthy individuals.
Design
Cross-sectional, comparative study.
Participants
A total of 140 participants were included in the study and divided into 2 groups:
70 patients diagnosed with FUS (FUS group) and 70 healthy individuals (control group).
Methods
The groups were compared in terms of ocular examination findings and CBC parameters.
The independent samples t test was used to examine variables between the groups. The Pearson correlation test
was performed to analyze correlation among the severity of anterior chamber reaction,
duration of FUS, and CBC indices.
Results
The mean lymphocyte count and lymphocyte-to-monocyte ratio (LMR) were significantly
higher in the FUS group than in the control group (p = 0.001 and p < 0.001, respectively). The mean monocyte count and neutrophil-to-lymphocyte ratio
(NLR) were significantly lower in the FUS group than in the control group (p = 0.010 and p = 0.003, respectively). In the receiver operating characteristic curve analysis,
the area under the curve (AUC) for LMR was 0.834, with a sensitivity of 82.6% and
a specificity of 80.0%. The AUC for NLR was 0.789, with a sensitivity of 71.2% and
a specificity of 70.0%. LMR was positively correlated with duration of FUS (p = 0.001, r = 0.574).
Conclusions
Our findings suggest that decreased NLR and increased LMR values may be markers indicating
impaired blood–aqueous barrier function in FUS.
Objectif
Évaluer les indices inflammatoires mis au jour dans la formule sanguine complète (FSC)
chez des patients présentant un syndrome uvéitique de Fuchs (FUS, pour Fuchs uveitis syndrome) et comparer les résultats à ceux de sujets sains.
Nature
Étude comparative transversale.
Participants
Les 140 participants ont été divisés en 2 groupes: 70 patients qui ont reçu un diagnostic
de FUS (groupe FUS) et 70 sujets en bonne santé (groupe témoin).
Méthodes
Les résultats de l'examen oculaire et les paramètres de la FSC ont été comparés. On
a eu recours au test t pour échantillons indépendants pour examiner les variables entre les 2 groupes. Le
test de corrélation de Pearson a servi à analyser la corrélation entre la gravité
de la réaction de la chambre antérieure, l'ancienneté du FUS et les paramètres de
la FSC.
Résultats
La numération lymphocytaire moyenne et le rapport lymphocytes/monocytes (RLM) moyen
étaient significativement plus élevés dans le groupe FUS, comparativement au groupe
témoin (p = 0,001 et p < 0,001, respectivement). Par ailleurs, le taux de monocytes
moyen et le rapport neutrophiles/lymphocytes (RNL) moyen étaient significativement
plus faibles dans le groupe FUS, comparativement au groupe témoin (p = 0,010 et p = 0,003,
respectivement). Selon l'analyse de la courbe de fonction d'efficacité du récepteur,
l'aire sous la courbe (ASC) du RLM était de 0,834, la sensibilité et la spécificité
de ce paramètre se chiffrant à 82,6 % et à 80,0 %, respectivement. L'ASC du RNL était
de 0,789, la sensibilité et la spécificité de ce paramètre se chiffrant à 71,2 % et
à 70,0 %, respectivement. On a enregistré une corrélation positive entre le RLM et
l'ancienneté du FUS (p = 0,001; r = 0,574).
Conclusions
Notre étude porte à croire qu'une baisse du RNL et une hausse du RLM indiqueraient
la présence d'une altération de la fonction de la barrière hémato-aqueuse dans le
FUS.
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Article info
Publication history
Published online: November 21, 2020
Accepted:
October 25,
2020
Received in revised form:
October 21,
2020
Received:
May 30,
2020
Identification
Copyright
© 2020 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
