Inflammatory markers of complete blood count in Fuchs uveitis syndrome

  • Mert Simsek
    Correspondence to Mert Simsek, MD, University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Kale Mahallesi, Ulucanlar Caddesi, No. 59, 06250, Altındağ, Ankara, Turkey.
    Department of Ophthalmology, University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey
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  • Pinar Cakar Ozdal
    Department of Ophthalmology, University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey
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Published:November 21, 2020DOI:



      To evaluate inflammatory indices of complete blood count (CBC) in patients with Fuchs uveitis syndrome (FUS), and to compare the results with healthy individuals.


      Cross-sectional, comparative study.


      A total of 140 participants were included in the study and divided into 2 groups: 70 patients diagnosed with FUS (FUS group) and 70 healthy individuals (control group).


      The groups were compared in terms of ocular examination findings and CBC parameters. The independent samples t test was used to examine variables between the groups. The Pearson correlation test was performed to analyze correlation among the severity of anterior chamber reaction, duration of FUS, and CBC indices.


      The mean lymphocyte count and lymphocyte-to-monocyte ratio (LMR) were significantly higher in the FUS group than in the control group (p = 0.001 and p < 0.001, respectively). The mean monocyte count and neutrophil-to-lymphocyte ratio (NLR) were significantly lower in the FUS group than in the control group (p = 0.010 and p = 0.003, respectively). In the receiver operating characteristic curve analysis, the area under the curve (AUC) for LMR was 0.834, with a sensitivity of 82.6% and a specificity of 80.0%. The AUC for NLR was 0.789, with a sensitivity of 71.2% and a specificity of 70.0%. LMR was positively correlated with duration of FUS (p = 0.001, r = 0.574).


      Our findings suggest that decreased NLR and increased LMR values may be markers indicating impaired blood–aqueous barrier function in FUS.


      Évaluer les indices inflammatoires mis au jour dans la formule sanguine complète (FSC) chez des patients présentant un syndrome uvéitique de Fuchs (FUS, pour Fuchs uveitis syndrome) et comparer les résultats à ceux de sujets sains.


      Étude comparative transversale.


      Les 140 participants ont été divisés en 2 groupes: 70 patients qui ont reçu un diagnostic de FUS (groupe FUS) et 70 sujets en bonne santé (groupe témoin).


      Les résultats de l'examen oculaire et les paramètres de la FSC ont été comparés. On a eu recours au test t pour échantillons indépendants pour examiner les variables entre les 2 groupes. Le test de corrélation de Pearson a servi à analyser la corrélation entre la gravité de la réaction de la chambre antérieure, l'ancienneté du FUS et les paramètres de la FSC.


      La numération lymphocytaire moyenne et le rapport lymphocytes/monocytes (RLM) moyen étaient significativement plus élevés dans le groupe FUS, comparativement au groupe témoin (p = 0,001 et p < 0,001, respectivement). Par ailleurs, le taux de monocytes moyen et le rapport neutrophiles/lymphocytes (RNL) moyen étaient significativement plus faibles dans le groupe FUS, comparativement au groupe témoin (p = 0,010 et p = 0,003, respectivement). Selon l'analyse de la courbe de fonction d'efficacité du récepteur, l'aire sous la courbe (ASC) du RLM était de 0,834, la sensibilité et la spécificité de ce paramètre se chiffrant à 82,6 % et à 80,0 %, respectivement. L'ASC du RNL était de 0,789, la sensibilité et la spécificité de ce paramètre se chiffrant à 71,2 % et à 70,0 %, respectivement. On a enregistré une corrélation positive entre le RLM et l'ancienneté du FUS (p = 0,001; r = 0,574).


      Notre étude porte à croire qu'une baisse du RNL et une hausse du RLM indiqueraient la présence d'une altération de la fonction de la barrière hémato-aqueuse dans le FUS.
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