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Evaluation of choroidal thickness and choroidal vascularity index during pregnancy

Published:January 06, 2021DOI:https://doi.org/10.1016/j.jcjo.2020.12.002

      Abstract

      Objective

      To assess the choroidal structural characteristics in the first and third trimesters in pregnant women using enhanced depth imaging optical coherence tomography and binarization method.

      Design

      Prospective study.

      Participants

      Twenty-five eyes of 25 pregnant women in the first trimester (group 1) and 25 eyes of 25 pregnant women in the third trimester (group 2) were examined. Healthy age-matched 25 participants were enrolled as a control group (group 3).

      Methods

      The choroidal thickness (CT) was measured at 3 points; subfoveal, 1500 μm nasal to the fovea, and 1500 μm temporal to the fovea. Total choroidal area, luminal area, stromal area, stroma/lumen ratio, and choroidal vascularity index (CVI) were measured by Image-J software.

      Results

      The mean subfoveal and nasal CT were statistically significantly increased in group 1 compared with controls (p = 0.005 and p = 0.004, respectively). The mean temporal CT was statistically significantly increased in group 1 compared with groups 2 and 3 (group 1 vs group 2, p = 0.043; group 1 vs group 3, p = 0.011). The mean total choroidal area, stromal area, and luminal area were significantly increased in groups 1 and 2 compared with control group (p < 0.001, p < 0.001, p < 0.001, and p < 0.001, p = 0.002, p = 0.002, respectively). There were no statistically significant differences among groups in terms of mean stroma/lumen ratio and CVI (p = 0.148 and p = 0.312, respectively).

      Conclusions

      There was a significant increase in subfoveal, temporal, and nasal CT in the first trimester. Total choroidal, stromal, and luminal areas were significantly increased in the first and third trimesters.

      Objectif

      Évaluer les caractéristiques de la structure de la choroïde pendant le premier et le troisième trimestre de la grossesse à l'aide de la tomographie par cohérence optique à l'imagerie à profondeur améliorée et d'une stratégie de binarisation.

      Nature

      Étude prospective.

      Participants

      Ont été examinés 25 yeux de 25 femmes au premier trimestre de la grossesse (groupe 1) et 25 yeux de 25 femmes au troisième trimestre de la grossesse (groupe 2). Le groupe témoin (groupe 3) était formé de 25 participantes appariées pour l’âge et en bonne santé (groupe 3).

      Méthodes

      On a mesuré l’épaisseur de la choroïde (EC) à 3 endroits : dans la sous-fovéa, à 1500 μm en nasal de la fovéa et à 1500 μm en temporal de la fovéa. On a eu recours au logiciel ImageJ pour mesurer la surface totale de la choroïde, la zone luminale, la zone stromale, le rapport stroma/lumen et l'indice de vascularisation choroïdienne (CVI, pour choroidal vascularity index).

      Résultats

      L'EC sous-fovéale et nasale moyenne était significativement plus élevée dans le groupe 1, comparativement au groupe témoin (p = 0,005 et p = 0,004, respectivement). De même, l'EC temporale moyenne était significativement plus élevée dans le groupe 1, comparativement aux groupes 2 et 3 (groupe 1 vs groupe 2, p = 0,043; groupe 1 vs groupe 3, p = 0,011). La surface totale de la choroïde, la zone stromale et la zone luminale moyenne étaient significativement plus élevées dans les groupes 1 et 2, comparativement au groupe témoin (p < 0,001; p < 0,001; p < 0,001 et p < 0,001; p = 0,002; p = 0,002, respectivement). On n'a noté aucune différence statistiquement significative entre les groupes quant au rapport stroma/lumen ni au CVI moyen (p = 0,148 et p = 0,312, respectivement).

      Conclusions

      On a enregistré une hausse significative de l'EC sous-fovéale, temporale et nasale pendant le premier trimestre de la grossesse. La surface totale de la choroïde, la zone stromale et la zone luminale moyenne, quant à elles, étaient significativement plus élevées pendant le premier et le troisième trimestre de la grossesse.
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