Abstract
Objective
Recurrent aphthous stomatitis (RAS) is the major finding of Behçet's disease as well
as an inflammatory disease. We compared the choroidal thickness (CT) in patients with
RAS with healthy volunteers.
Methods
Patients with RAS (n = 34) and age- and sex-matched controls (n = 34) were evaluated
using spectral-domain optical coherence tomography (OCT). CT measurements were executed
at 3 different points (subfoveal, nasal, and temporal). Laboratory parameters were
determined for patients and controls.
Results
The mean subfoveal CT in the RAS and control groups were 356.7 ± 91.7 μm and 326.3
± 86.6 μm, respectively. The RAS group demonstrated significantly higher subfoveal
CT than the control group (p = 0.008).
Conclusion
This was the first reported study demonstrating a significantly higher subfoveal CT
in patients with RAS. Further studies investigating the risk for subclinical ocular
inflammation in this patient population are warranted.
Objectif
La stomatite aphteuse récurrente (SAR) est le principal symptôme de la maladie de
Behçet et constitue en soi une atteinte inflammatoire. Nous avons comparé l’épaisseur
de la choroïde (EC) chez des patients présentant une SAR à celle de volontaires sains.
Méthodes
On a eu recours à la tomographie par cohérence optique (OCT, pour optical coherence tomography) en domaine spectral pour évaluer les patients présentant une SAR (n = 34) et des
sujets témoins appariés pour l’âge et le sexe (n = 34). L'EC a été mesurée dans 3 zones
(sous-fovéale, nasale et temporale). Ont également été évalués les paramètres de laboratoire
de l'ensemble des sujets.
Résultats
L’épaisseur sous-fovéale moyenne de la choroïde dans les groupes SAR et témoin se
chiffrait respectivement à 356,7 ± 91,7 μm et à 326,3 ± 86,6 μm, mesure qui était
significativement supérieure dans le groupe SAR, comparativement au groupe témoin
(p = 0,008).
Conclusion
Il s'agissait de la première étude à mettre au jour une augmentation significative
de l’épaisseur sous-fovéale de la choroïde en présence de SAR. Il serait important
de réaliser d'autres études sur le risque d'inflammation oculaire subclinique au sein
de cette population.
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Article info
Publication history
Published online: January 05, 2021
Accepted:
December 11,
2020
Received in revised form:
December 9,
2020
Received:
July 28,
2020
Identification
Copyright
© 2020 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
