Abstract
Objective
To compare the weight and insulin-like growth factor-1 in neonatal retinopathy (WINROP)
to the growth and retinopathy of prematurity (G-ROP) model in a Portuguese cohort.
Design
Retrospective case series.
Methods
Clinical records of consecutive infants who underwent retinopathy of prematurity (ROP)
screening from April 2012 to May 2019 were retrospectively reviewed. Both WINROP and
G-ROP models were accessed for sensitivity and specificity for type 1 ROP. A separate
analysis of both algorithms was performed in infants with gestational age (GA) <30
weeks.
Results
Of the 375 infants included in the study, 313 were eligible for G-ROP analysis and
311 for WINROP. In the G-ROP group, 22 infants developed type 1 ROP (sensitivity 90.91%,
95% confidence interval [CI] 70.84%–98.98%). In the WINROP group, 23 infants needed
treatment (sensitivity of 86.96%, 95% CI 66.41%–97.22%). Both models reached 100%
sensitivity for type 1 ROP if restricted to GA <30 weeks.
Conclusions
Both models were easy to use and had similar sensitivities. If restricted to GA <30
weeks, both models detected all type 1 ROP.
Résumé
Objectif
Comparer l'algorithme winrop® établissant un lien entre le poids et l'IGF-1 (insulin-like growth factor-1 ou somatomédine C) dans la rétinopathie du nouveau-né au modèle G-ROP (growth-retinopathy of prematurity) associant la croissance et la rétinopathie du prématuré (RDP) au sein d'une cohorte
portugaise.
Nature
Étude rétrospective d'une série de cas.
Méthodes
On a procédé à l'examen rétrospectif des dossiers médicaux de nourrissons consécutifs
qui ont subi un dépistage de la rétinopathie du prématuré (RDP) entre avril 2012 et
mai 2019. On a vérifié la sensibilité et la spécificité de l'algorithme winrop® et
du modèle G-ROP quant au dépistage de la RDP de type 1. Une analyse distincte des
2 algorithmes a été réalisée chez des nourrissons dont l’âge gestationnel (AG) était
< 30 semaines.
Résultats
Sur les 375 nourrissons qui ont été inclus à l’étude, 313 étaient admissibles à l'analyse
au moyen du modèle G-ROP et 311, au moyen de l'algorithme winrop®. Dans le groupe
G-ROP, 22 nourrissons ont présenté une RDP de type 1 (sensibilité de 90,91 %; intervalle
de confiance [IC] à 95 % : 70,84 %–98,98 %). Dans le groupe algorithme winrop®, 23
nourrissons ont dû recevoir un traitement (sensibilité de 86,96 %; IC à 95 % : 66,41 %–97,22 %).
Les 2 modèles ont obtenu une sensibilité de 100 % pour ce qui est du dépistage de
la RDP de type 1 si l'on se limitait aux nourrissons dont l'AG était < 30 semaines.
Conclusions
Les 2 modèles ont été faciles à utiliser et offraient une sensibilité semblable. Lorsque
l'on se limitait aux nourrissons dont l'AG était < 30 semaines, les 2 modèles permettaient
le dépistage de tous les cas de RDP de type 1.
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Article Info
Publication History
Published online: March 23, 2021
Accepted:
February 18,
2021
Received in revised form:
February 14,
2021
Received:
September 20,
2020
Identification
Copyright
© 2021 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
