Abstract
Objective
To compare and correlate retinal sensitivities measured with macular integrity assessment
microperimetry (MAIA-MP) and Humphrey field analyzer (HFA) 10-2 tests with structural
parameters obtained from optical coherence tomography (OCT) in primary open-angle
glaucoma (POAG) and ocular hypertension.
Methods
This study included 63 participants (22 with POAG, 20 with ocular hypertension, and
21 control individuals). All participants underwent HFA 10-2 and MAIA-MP (macular
retinal sensitivity tests) and measurements for optic nerve head (ONH), peripapillary
retinal nerve fibre layer thickness (PRNFLT), and ganglion cell inner plexiform layer
thickness (GCIPLT) using OCT. The relationship between macular retinal sensitivity
and OCT parameters was evaluated by Pearson correlation analysis and linear regression
modelling.
Results
POAG cases had a strong association between the MAIA-MP and ONH parameters (optic
disc area [ODA], p = 0.037; cup volume, p = 0.043), PRNFLT (average, p = 0.009; inferior PRNFLT, p = 0.004), and GCIPLT in all macula sectors (p ≤ 0.005 for all). HFA 10-2 had a moderate correlation with the ONH parameters (cup-to-disc
ratio [CDR], p = 0.042; vertical CDR, p = 0.037; cup volume, p = 0.037; ODA, p = 0.014), PRNFLT (average, inferior, and nasal, p < 0.05 for all), and GCIPLT in all macula sectors (p < 0.005 for all). OHT cases had a weak correlation between HFA 10-2 and nasal and
superior PRNFLTs (p = 0.035 and p = 0.047, respectively).
Conclusion
MAIA-MP and HFA 10-2 functional parameters have strong correlations with the structural
parameters obtained by OCT in POAG cases. Both devices are useful in assessing the
central visual field in glaucoma, with MAIA-MP potentially beneficial in patients
with limited cooperation or poor vision.
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Article Info
Publication History
Published online: August 03, 2021
Accepted:
July 6,
2021
Received in revised form:
May 17,
2021
Received:
January 9,
2021
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2021 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
