Multimodal imaging in perifoveal unilateral retinal pigment epithelium dysgenesis

Published:September 30, 2021DOI:
      A 16-year-old asymptomatic woman had a corrected visual acuity of 20/30 OS and 20/20 OD. The anterior segment of the left eye was unremarkable, whereas the fundus showed a well-demarcated flat perifoveal lesion with variegated pigmentation and scalloped margins (Fig. 1A) that was hypo/autofluorescent with a hyper/autofluorescent rim (B) with reverse pattern on fluorescein angiography—a hyperfluorescent centre with a hypofluorescent rim (C). Swept-source optical coherence tomography revealed retinal pigment epithelium loss with hypertransmission (black arrowhead) adjacent to a region of increased retinal pigment epithelium reflectivity and thickening (blue arrowhead, D). The right eye was essentially normal. A diagnosis of unilateral perifoveal retinal pigment epithelium dysgenesis was made, and the patient was followed up.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Canadian Journal of Ophthalmology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect