Abstract
Objective
This study aims to synthesize data quantifying the prevalence and severity of common
psychological conditions in patients with glaucoma.
Design
Systematic review and meta-analysis.
Methods
Databases including Ovid MEDLINE, CINAHL, EMBASE, PsycINFO, Cochrane Library, Web
of Science, Open Grey, and ProQuest Theses and dissertations were searched. Two reviewers
independently assessed and screened all studies, followed by quality assessment of
included studies using the modified Downs and Black checklist. Data were pooled using
fixed-effect and random-effects models.
Results
Of 2067 studies identified by the search strategy, 57 passed full-text screening,
and 45 studies (4 995 538 subjects) were eligible for analysis. Overall, the prevalence
of depression (effect size [ES] = 0.19, 95% CI 0.16–0.23; n = 31), anxiety (ES = 0.25,
95% CI 0.21–0.30; n = 18), and sleep disorders (ES = 0.47, 95% CI 0.26–0.68; n = 7)
were high in patients with glaucoma. Similarly, symptomatic measurements of depression
(standardized mean difference [SMD] = 0.46, 95% CI 0.19–0.73), anxiety (SMD = 0.44,
95% CI 0.08–0.81), and sleep quality (SMD = 0.72, 95% CI 0.22–1.21) were significant
in glaucoma patients.
Conclusions
A higher prevalence and severity of depression, anxiety, and sleep disorders was experienced
in patients with glaucoma compared with patients without glaucoma. Caregivers as well
as health care providers may need to be aware of unique psychological and social stressors
placed on glaucoma patients.
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Article Info
Publication History
Published online: March 16, 2022
Accepted:
February 12,
2022
Received in revised form:
February 7,
2022
Received:
April 10,
2020
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
