Abstract
Objective
To evaluate the accuracy of peripapillary optical coherence tomography angiography
(OCTA) segmentation in eyes with acute nonarteritic anterior ischemic optic neuropathy
(NAION) and healthy eyes.
Method
In this retrospective study, en face OCTA images of the optic disc of healthy eyes
and eyes with unilateral acute NAION were obtained. The disc boundary and radial peripapillary
capillary (RPC) segmentation were generated automatically by the instrument software
and then corrected by 2 expert investigators. The frequency of segmentation errors
and its impact on vessel density and nerve fibre layer (NFL) thickness measurements
were evaluated.
Results
Thirty-eight eyes of 38 subjects (18 in the healthy group and 20 in the acute NAION
group) were studied. A misidentified disc border was noted in 5 healthy eyes (27.7%)
and 19 eyes with NAION (95.0%; p < 0.001). Segmentation error at the RPC level was found in 6 healthy eyes (33.33%)
and 19 eyes with NAION (95.0%; p < 0.001). The nerve fibre layer thickness and RPC density did not change statistically
significantly after error corrections in both groups.
Conclusions
Misidentification of disc border and segmentation error of the RPC layer are common
in OCTA images of the optic disc. Accuracy of OCTA imaging in disc boundary detection
and RPC network segmentation is reduced in edematous optic discs following acute NAION.
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Article Info
Publication History
Published online: July 19, 2022
Accepted:
June 23,
2022
Received in revised form:
April 7,
2022
Received:
December 26,
2021
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
