Advertisement

Accuracy of peripapillary OCTA in patients with acute nonarteritic anterior ischemic optic neuropathy

      Abstract

      Objective

      To evaluate the accuracy of peripapillary optical coherence tomography angiography (OCTA) segmentation in eyes with acute nonarteritic anterior ischemic optic neuropathy (NAION) and healthy eyes.

      Method

      In this retrospective study, en face OCTA images of the optic disc of healthy eyes and eyes with unilateral acute NAION were obtained. The disc boundary and radial peripapillary capillary (RPC) segmentation were generated automatically by the instrument software and then corrected by 2 expert investigators. The frequency of segmentation errors and its impact on vessel density and nerve fibre layer (NFL) thickness measurements were evaluated.

      Results

      Thirty-eight eyes of 38 subjects (18 in the healthy group and 20 in the acute NAION group) were studied. A misidentified disc border was noted in 5 healthy eyes (27.7%) and 19 eyes with NAION (95.0%; p < 0.001). Segmentation error at the RPC level was found in 6 healthy eyes (33.33%) and 19 eyes with NAION (95.0%; p < 0.001). The nerve fibre layer thickness and RPC density did not change statistically significantly after error corrections in both groups.

      Conclusions

      Misidentification of disc border and segmentation error of the RPC layer are common in OCTA images of the optic disc. Accuracy of OCTA imaging in disc boundary detection and RPC network segmentation is reduced in edematous optic discs following acute NAION.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Canadian Journal of Ophthalmology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Abri Aghdam K
        • Ashraf Khorasani M
        • Soltan Sanjari M
        • et al.
        Optical coherence tomography angiography features of optic nerve head drusen and nonarteritic anterior ischemic optic neuropathy.
        Can J Ophthalmol. 2019; 54: 495-500
        • Akil H
        • Falavarjani KG
        • Sadda SR
        • Sadun AA.
        Optical coherence tomography angiography of the optic disc: an overview.
        J Ophthalmic Vis Res. 2017; 12: 98-105
        • Pujari A
        • Bhaskaran K
        • Sharma P
        • et al.
        Optical coherence tomography angiography in neuro-ophthalmology: current clinical role and future perspectives.
        Surv Ophthalmol. 2021; 66: 471-481
        • Mase T
        • Ishibazawa A
        • Nagaoka T
        • Yokota H
        • Yoshida A.
        Radial peripapillary capillary network visualized using wide-field montage optical coherence tomography angiography.
        Invest Ophthalmol Vis Sci. 2016; 57: 504-510
        • Mo S
        • Phillips E
        • Krawitz BD
        • et al.
        Visualization of radial peripapillary capillaries using optical coherence tomography angiography: the effect of image averaging.
        PLoS One. 2017; 12e0169385
        • Rougier MB
        • Le Goff M
        • Korobelnik JF
        Optical coherence tomography angiography at the acute phase of optic disc edema.
        Eye Vis (Lond). 2018; 5: 15
        • Anvari P
        • Ashrafkhorasani M
        • Habibi A
        • Falavarjani KG.
        Artifacts in optical coherence tomography angiography.
        J Ophthalmic Vis Res. 2021; 16: 271-286
        • Baek J
        • Jeon SJ
        • Kim JH
        • Park CK
        • Park HL.
        Optic disc vascular density in normal-tension glaucoma eyes with or without branch retinal vessel occlusion.
        J Clin Med. 2021; 10: 12
        • Frizziero L
        • Parrozzani R
        • Londei D
        • Pilotto E
        • Midena E.
        Quantification of vascular and neuronal changes in the peripapillary retinal area secondary to diabetic retinopathy.
        Br J Ophthalmol. 2021; 105: 1577-1583
        • Sharma S
        • Ang M
        • Najjar RP
        • et al.
        Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy.
        Br J Ophthalmol. 2017; 101: 1045-1051
        • Wang X
        • Han Y
        • Sun G
        • et al.
        Detection of the microvascular changes of diabetic retinopathy progression using optical coherence tomography angiography.
        Transl Vis Sci Technol. 2021; 10: 31
      1. Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the Ischemic Optic Neuropathy Decompression Trial.
        Arch Ophthalmol. 1996; 114: 1366-1374
        • Reis AS
        • O'Leary N
        • Yang H
        • et al.
        Influence of clinically invisible, but optical coherence tomography detected, optic disc margin anatomy on neuroretinal rim evaluation.
        Invest Ophthalmol Vis Sci. 2012; 53: 1852-1860
        • Ghasemi Falavarjani K
        • Habibi A
        • Anvari P
        • et al.
        Effect of segmentation error correction on optical coherence tomography angiography measurements in healthy subjects and diabetic macular oedema.
        Br J Ophthalmol. 2020; 104: 162-166
        • Ghasemi Falavarjani K
        • Mirshahi R
        • Ghasemizadeh S
        • Sardarinia M
        Stepwise segmentation error correction in optical coherence tomography angiography images of patients with diabetic macular edema.
        Ther Adv Ophthalmol. 2020; 122515841420947931
        • Kamalipour A
        • Moghimi S
        • Hou H
        • et al.
        OCT angiography artifacts in glaucoma.
        ophthalmology. 2021; 128: 1426-1437
        • Hanna V
        • Sharpe GP
        • West ME
        • et al.
        Peripapillary retinal segmentation in OCT angiography.
        Ophthalmology. 2020; 127: 1770-1772