The data from studies regarding efficacy of vitamin D supplementation for fracture reduction have shown conflicting results. To provide further evidence regarding whether vitamin D is beneficial in fracture reduction, researchers conducted an ancillary study in the Vitamin D and Omega=3 Trial (VITAL). There were 25 781 individuals enrolled and randomly assigned to placebo or vitamin D up to 800 IU per day in conjunction with at least 1200 mg of calcium. Participants were followed up for a median of 5.3 years, with fracture occurrence determined by patient questionnaire and a centralized medical records review. An intent-to-treat analysis using proportional hazards models was conducted, and subgroup analysis was stratified by baseline 25-hydroyvitamin D levels. Over the course of the study, there were 1991 fractures in 1551 participants and the data analysis found there was no benefit in fracture reduction from vitamin D supplementation, even for participants who had initial levels below 20 ng/ml. Of the total fractures, 769 occurred in 12 927 participants in the vitamin D group, and 782 of fractures occurred in the 12 944 controls (0.98 hazard ratio, 95% confidence interval 0.89 to 1.08, p=0.7). There was no significant effect of vitamin D supplementation for the occurrence of nonvertebral fractures (p=0.5) or hip fractures (p=0.96). The authors concluded that vitamin D supplementation did not result in a lower risk of fractures.
LeBoff M, Chou S, Ratliff K et al. Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults. N Engl J Med 2022; 387:299-309. DOI: 10.1056/NEJMoa2202106
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Canadian Journal of Ophthalmology
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
F. Y. Eye presents summaries of publications and news stories of interest to ophthalmologists. If you have any suggestions or contributions, please send them to Ian McIlraith at [email protected]