Abstract
Objective
To study the relationships of functional and morphologic retinal parameters in a series
of pediatric patients with varying degrees of foveal hypoplasia (FH).
Design
Monocentric observational retrospective study.
Participants
Among 21 pediatric patients, 16 met inclusion criteria, having FH confirmed with spectral-domain
optical coherence tomography (SD-OCT) scan
Methods
Data were analyzed retrospectively. Patients able to undergo macular microperimetry
(MP) and SD-OCT examinations were included in the analysis. MP and SD-OCT outcomes
were compared with FH grading and best-corrected visual acuity (BCVA) using Pearson's
correlation.
Results
Thirty-one eyes from 16 patients (mean age 12.4 years) with different degrees of FH
were analyzed. Two patients had grade 1, 7 had grade 2, 5 had grade 3, and 2 had grade
4 FH. Clinical nystagmus was present in 8 patients. The correlation between BCVA and
SD-OCT data (–0.31) was lower than that found between BCVA and nystagmus (0.64), that
for fixation index P1 (–0.60), as well as that for macular sensitivity (–0.63).
Conclusions
Although limited by the small sample, our study confirms the feasibility of automated
MP evaluation in pediatric patients with FH. The added value of this work is the provision
of data on relationships between anatomic and functional macular measurements acquired
with SD-OCT, MP, and BCVA in eyes with various degrees of FH. Larger prospective studies
are necessary to confirm these results.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Canadian Journal of OphthalmologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Ophthalmic manifestation of congenital protein C deficiency.J AAPOS. 1999; 3: 188-190
- Retinal structure and function in achromatopsia: implications for gene therapy.Ophthalmology. 2014; 121: 234-245
- Structural grading of foveal hypoplasia using spectral-domain optical coherence tomography a predictor of visual acuity?.Ophthalmology. 2011; 118: 1653-1660
- A new recessively inherited disorder composed of foveal hypoplasia, optic nerve decussation defects and anterior segment dysgenesis maps to chromosome 16q23.3-24.1.Mol Vis. 2013; 19: 2165-2172
- Foveal hypoplasia in oculocutaneous albinism demonstrated by optical coherence tomography.Am J Ophthalmol. 2002; 133: 409-410
- Visual insignificance of the foveal pit: reassessment of foveal hypoplasia as fovea plana.Arch Ophthalmol. 2008; 126: 907-913
- Novel mutations in MFRP and PRSS56 are associated with posterior microphthalmos.Ophthalmic Genet. 2020; 41: 49-56
- Foveal abnormalities determined by optical coherence tomography angiography in children with history of retinopathy of prematurity.Eye (Lond). 2019; 33: 1890-1896
- Isolated foveal hypoplasia: clinical presentation and imaging findings.Optom Vis Sci. 2014; 91: S61-S65
- Isolated foveal hypoplasia without nystagmus.Int Ophthalmol. 2014; 34: 877-880
- Isolated foveal hypoplasia: report of a new case and detailed genetic investigation.Int Ophthalmol. 2011; 31: 117-120
- Isolated foveal hypoplasia.Int Ophthalmol. 2009; 29: 271-274
- Histologic development of the human fovea from midgestation to maturity.Am J Ophthalmol. 2012; 154 (e762): 767-778
- Spectral domain optical coherence tomography and microperimetry in foveal hypoplasia.Indian J Ophthalmol. 2011; 59: 503-505
- Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism.Ophthalmology. 2007; 114: 1547-1551
- Rehabilitation with biofeedback training in age-related macular degeneration for improving distance vision.Can J Ophthalmol. 2019; 54: 328-334
- Feasibility of macular integrity assessment (MAIA) microperimetry in children: sensitivity, reliability, and fixation stability in healthy observers.Invest Ophthalmol Vis Sci. 2016; 57: 6349-6359
- Preferred retinal locus profile during prolonged fixation attempts.Can J Ophthalmol. 2013; 48: 368-374
- Reference clinical database for fixation stability metrics in normal subjects measured with the MAIA microperimeter.Trans Vis Sci Technol. 2016; 5: 6
- Patient selection for macular translocation surgery using the scanning laser ophthalmoscope.Ophthalmology. 2002; 109: 1737-1744
- Optical coherence tomography angiography of foveal hypoplasia.Br J Ophthalmol. 2017; 101: 985-988
- The clinical phenotype of CNGA3-related achromatopsia: pretreatment characterization in preparation of a gene replacement therapy trial.Invest Ophthalmol Vis Sci. 2017; 58: 821-832
- Optical coherence tomography is helpful in the diagnosis of foveal hypoplasia.Acta Ophthalmol. 2010; 88: 439-442
- Spectrum of foveal development in albinism detected with optical coherence tomography.J AAPOS. 2006; 10: 237-242
Article Info
Publication History
Published online: November 21, 2022
Accepted:
October 22,
2022
Received in revised form:
August 17,
2022
Received:
September 18,
2021
Publication stage
In Press Corrected ProofFootnotes
The Abstract of this article was presented at the World Society of Paediatric Ophthalmology and Strabismus Subspecialty Day, held in Paris, France, on September 13, 2019.
Identification
Copyright
© 2022 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
