Abstract
Objective
To study the relationships of functional and morphologic retinal parameters in a series
of pediatric patients with varying degrees of foveal hypoplasia (FH).
Design
Monocentric observational retrospective study.
Participants
Among 21 pediatric patients, 16 met inclusion criteria, having FH confirmed with spectral-domain
optical coherence tomography (SD-OCT) scan
Methods
Data were analyzed retrospectively. Patients able to undergo macular microperimetry
(MP) and SD-OCT examinations were included in the analysis. MP and SD-OCT outcomes
were compared with FH grading and best-corrected visual acuity (BCVA) using Pearson's
correlation.
Results
Thirty-one eyes from 16 patients (mean age 12.4 years) with different degrees of FH
were analyzed. Two patients had grade 1, 7 had grade 2, 5 had grade 3, and 2 had grade
4 FH. Clinical nystagmus was present in 8 patients. The correlation between BCVA and
SD-OCT data (–0.31) was lower than that found between BCVA and nystagmus (0.64), that
for fixation index P1 (–0.60), as well as that for macular sensitivity (–0.63).
Conclusions
Although limited by the small sample, our study confirms the feasibility of automated
MP evaluation in pediatric patients with FH. The added value of this work is the provision
of data on relationships between anatomic and functional macular measurements acquired
with SD-OCT, MP, and BCVA in eyes with various degrees of FH. Larger prospective studies
are necessary to confirm these results.
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Article info
Publication history
Published online: November 21, 2022
Accepted:
October 22,
2022
Received in revised form:
August 17,
2022
Received:
September 18,
2021
Publication stage
In Press Corrected ProofFootnotes
The Abstract of this article was presented at the World Society of Paediatric Ophthalmology and Strabismus Subspecialty Day, held in Paris, France, on September 13, 2019.
Identification
Copyright
© 2022 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.
