Original Article|Articles in Press

Retinal characteristics in eyes with pathologic myopia among individuals self-identifying as Black

Published:February 13, 2023DOI:



      Investigate retinal characteristics of pathologic myopia (PM) among patients self-identifying as Black.


      Retrospective cohort single-institution retrospective medical record review.


      Adult patients between January 2005 and December 2014 with International Classification of Diseases (ICD) codes consistent with PM and given 5-year follow-up were evaluated. The Study Group consisted of patients self-identifying as Black, and the Comparison Group consisted of those not self-identifying as Black. Ocular features at study baseline and 5-year follow-up visit were evaluated.


      Among 428 patients with PM, 60 (14%) self-identified as Black and 18 (30%) had baseline and 5-year follow-up visits. Of the remaining 368 patients, 63 were in the Comparison Group. For the study (n = 18) and Comparison Group (n = 29), median (25th percentile, 75th percentile) baseline visual acuity was 20/40 (20/25, 20/50) and 20/32 (20/25, 20/50) in the better-seeing eye and 20/70 (20/50, 20/1400) and 20/100 (20/50, 20/200), respectively, in the worse-seeing eye. In the eyes that did not have choroidal neovascularization (CNV) in the study and Comparison Group, median study baseline optical coherence tomography central subfield thickness was 196 μm (169, 306 μm) and 225 μm (191, 280 μm), respectively, in the better-seeing eye and 208 μm (181, 260 μm) and 194 μm (171, 248 μm), respectively, in the worse-seeing eye. Baseline prevalence of CNV was 1 Study Group eye (3%) and 20 Comparison Group eyes (34%). By the 5-year visit, zero (0%) and 4 (15%) additional eyes had CNV in the study and Comparison Group, respectively.


      These findings suggest that the prevalence and incidence of CNV may be lower in patients with PM self-identifying as Black when compared with individuals of other races.
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        • Ohno-Matsui K
        Pathologic myopia.
        Asia-Pac J Ophthalmol. 2016; 5: 415-423
        • Vongphanit J
        • Mitchell P
        • Wang JJ.
        Prevalence and progression of myopic retinopathy in an older population.
        Ophthalmology. 2002; 109: 704-711
        • Liu HH
        • Xu L
        • Wang YX
        • Wang S
        • You QS
        • Jonas JB.
        Prevalence and progression of myopic retinopathy in Chinese adults: the Beijing Eye Study.
        Ophthalmology. 2010; 117: 1763-1768
        • Farinha CL
        • Baltar AS
        • Nunes SG
        • et al.
        Progression of myopic maculopathy after treatment of choroidal neovascularization.
        Ophthalmology. 2014; 231: 211-220
        • Verhoeven VJM
        • Wong KT
        • Buitendijk GHS
        • Hofman A
        • Vingerling JR
        • Klaver CCW.
        Visual consequences of refractive errors in the general population.
        Ophthalmology. 2015; 122: 101-109
        • Tan CS
        • Sadda SVR.
        Anti–vascular endothelial growth factor therapy for the treatment of myopic choroidal neovascularization.
        Clin Ophthalmol. 2017; 11: 1741-1746
        • Wu P-C
        • Chen C-T
        • Lin K-K
        • et al.
        Myopia prevention and outdoor light intensity in a school-based cluster randomized trial.
        Ophthalmology. 2018; 125: 1239-1250
        • Tan D
        • Tay SA
        • Loh K-L
        • Chia A.
        Topical atropine in the control of myopia.
        Asia-Pac J Ophthalmol. 2016; 5: 424-428
        • World Health Organization
        The impact of myopia and high myopia: report of the joint World Health Organization–Brien Holden Vision Institute Global Scientific Meeting on Myopia.
        University of New South Wales, Sydney, Australia2017 (May)
        • Wong TY
        • Ferreira A
        • Hughes R
        • Carter G
        • Mitchell P.
        Epidemiology and disease burden of pathologic myopia and myopic choroidal neovascularization: an evidence-based systematic review.
        Am J Ophthalmol. 2014; 157 (e12): 9-25
        • Takashima T.
        The quality of life in patients with pathologic myopia.
        Jpn J Ophthalmol. 2001; 45: 84-92
        • Yokoi T
        • Moriyama M
        • Hayashi K
        • et al.
        Predictive factors for comorbid psychiatric disorders and their impact on vision-related quality of life in patients with high myopia.
        Int Ophthalmol. 2013; 34: 171-183
        • Fang Y
        • Yokoi T
        • Nagaoka N
        • et al.
        Progression of myopic maculopathy during 18-year follow-up.
        Ophthalmology. 2018; 125: 863-877
        • Vitale S.
        Increased prevalence of myopia in the United States between 1971–1972 and 1999–2004.
        Arch Ophthalmol. 2009; 127: 1632
        • World Health Organization
        World report on vision.
        WHO, Geneva2019
        • Friedman DS
        • Katz J
        • Bressler NM
        • Rahmani B
        • Tielsch JM.
        Racial differences in the prevalence of age-related macular degeneration.
        Ophthalmology. 1999; 106: 1049-1055
        • Pieramici DJ.
        Choroidal neovascularization in black patients.
        Arch Ophthalmol. 1994; 112: 1043
        • Bressler SB
        • Edwards AR
        • et al.
        • Diabetic Retinopathy Clinical Research Network Writing Committee
        Reproducibility of spectral-domain optical coherence tomography retinal thickness measurements and conversion to equivalent time-domain metrics in diabetic macular edema.
        JAMA Ophthalmol. 2014; 132: 1113-1122
        • Bressler NM
        • Chang TS
        • Suñer IJ
        • et al.
        Vision-related function after ranibizumab treatment by better- or worse-seeing eye.
        Ophthalmology. 2010; 117 (e4): 747-756
        • Ohno-Matsui K
        • Kawasaki R
        • Jonas JB
        • et al.
        International photographic classification and grading system for myopic maculopathy.
        Am J Ophthalmol. 2015; 159 (e7): 877-883