- Neonatal herpes simplex virus (HSV) 2 infection seldom occurs with an incidence of 1 in 3000 live births in the United States.1,2 Most commonly the virus is acquired through the birth canal. Very rarely the infection is developed in utero, presumably transplacental via chorionic villi.1,3 In utero infections can cause pneumonitis, myocarditis, hepatosplenomegaly, encephalitis, hemolytic anemia, cerebral palsy, and mental delay.1 Ocular manifestations include cataracts, corneal ulceration, anterior uveitis, vitritis, chorioretinitis, and optic atrophy.
- We report the case of a premature infant born at 24 weeks postmenstrual age (PMA) with a birth weight of 652 g who was treated with intravitreal bevacizumab (IVB) in both eyes for zone 1, stage 3 retinopathy of prematurity (ROP) with plus disease. At 63 weeks PMA, he was treated successfully with repeat IVB injection in the right eye for recurrent vascular proliferation. At 92 weeks PMA, the right eye showed late recurrence of tractional fibrovascular proliferation (FVP) temporally, with no leakage, retinal detachment, macular ectopia, or disc dragging.