A 59-year-old female presented with right eye choroidal melanoma of 9×7 mm basal dimensions and 3.1-mm thickness (Fig. 1A). A complete work-up detected no evidence of systemic metastases. Her melanoma was classified as T1 N0 M0 tumour, categorized as stage I, based on the 7th edition of TNM cancer staging manual of the American Joint Committee on Cancer. The choroidal melanoma was treated with iodine 125 plaque brachytherapy that ultimately controlled the tumour locally. Two years after brachytherapy, a mild elevation of her liver transaminases was noticed.