x
Filter:
Filters applied
- Correspondence
- Rapid CommunicationRemove Rapid Communication filter
- Case ReportRemove Case Report filter
Publication Date
Please choose a date range between 2016 and 2019.
Author
- Lee, Andrew G5
- Hussain, Ahsen3
- Ansons, Alec2
- Damji, Karim F2
- Kakizaki, Hirohiko2
- Ajithkumar, Thankamma1
- Al-Awadi, Ahmad1
- Al-Marwani Al-Juhani, Maher F1
- Ali, Zaria Christine1
- Alsulaiman, Sulaiman M1
- Altomare, Filiberto1
- Anand, Seema1
- Anandula, Venkataramana1
- Angmo, Dewang1
- Antoniuk, Angela1
- Antoun, J1
- Arora, Sourabh1
- Arthurs, Bryan1
- Auteri, Nicholas J1
- Bang, Seung Pil1
- Barman, Manabjyoti1
- Bawankar, Pritam1
- Beaver, Hilary A1
- Belliveau, Michel J1
- Benitez-del-Castillo1
Correspondence
65 Results
- Case Report
Carotid artery dissection associated with Purtscher-like retinopathy
Canadian Journal of OphthalmologyVol. 55Issue 2e77–e79Published online: November 7, 2019- Shakeel Qazi
- Mathew M. Palakkamanil
- David I.T. Sia
- David S. Ehmann
Cited in Scopus: 3Purtscher retinopathy was first described in 1910 by Otmar Purtscher in a man who suffered a traumatic head injury.1 Patients commonly present with a loss of visual acuity and a recent history of injury such as head trauma or chest compression.2,3 In the case of a nontraumatic injury, the terminology commonly used is “Purtscher-like retinopathy.” It is associated with various systemic diseases, including acute pancreatitis, pancreatic adenocarcinoma, thrombotic thrombocytopenic purpura, connective tissue disorders, and hemolytic uremic syndrome. - Case Report
Severe chorioretinal atrophy in Boucher-Neuhauser syndrome
Canadian Journal of OphthalmologyVol. 55Issue 1e26–e28Published online: August 9, 2019- Laura Donaldson
- Mark A. Tarnopolsky
- James A. Martin
- Amadeo R. Rodriguez
Cited in Scopus: 4A 51-year-old woman was seen in the neuro-ophthalmology clinic. She reported difficulties with night vision dating back to approximately age 10 and an abnormal gait since childhood, which was described as unsteady and hesitant with stiffness of both legs. Ten years previously she was noted to have nystagmus by her family practitioner and was referred to an ophthalmologist, who diagnosed her with probable retinitis pigmentosa (RP). At that time, visual evoked potentials showed delayed P100 responses bilaterally. - Case Report
Wet age-related macular degeneration refractory to aflibercept but responsive to systemic everolimus
Canadian Journal of OphthalmologyVol. 55Issue 1e18–e20Published online: July 1, 2019- David Ta Kim
- Filiberto Altomare
Cited in Scopus: 1A 69-year-old Caucasian woman with a history of metastatic breast cancer had been receiving injections of aflibercept every 4–8 weeks for wet age-related macular degeneration in her right eye for the past 4 years. Despite the regular frequency of the aflibercept injections, her optical coherence tomography had always demonstrated significant levels of intraretinal fluid (Fig. 1). It was decided in the past to maintain her schedule of aflibercept in order to maintain her baseline level of vision of 20/60. - Case Report
Triple-hit lymphoma of the cavernous sinus
Canadian Journal of OphthalmologyVol. 54Issue 2e61–e66Published online: August 28, 2018- Jeffrey Tran
- Aroucha Vickers
- Claudia Prospero Ponce
- Swaminathan P. Iyer
- Andrew G. Lee
Cited in Scopus: 2Diffuse large B-cell lymphoma (DLBCL) is the most common non–Hodgkin-type lymphoma in adults, and the myriad of clinical presentations is well known to neuro-ophthalmologists.1 Traditionally, DLBCL was treated with standard chemotherapy, including R-CHOP (i.e., rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). Newer cytogenetic, fluorescent in situ hybridization (FISH), and next-generation sequencing (NGS) techniques, however, have shown the presence of genomic abnormalities that have significant treatment and prognostic implications. - Correspondence
Concurrent cerebral toxoplasmosis and cytomegalovirus retinitis in a patient with human immunodeficiency virus
Canadian Journal of OphthalmologyVol. 54Issue 1e33–e35Published online: June 18, 2018- Dulanji K. Kuruppu
- G. Paolo Giuliari
- Devin D. Mackay
Cited in Scopus: 1A 35-year-old previously healthy female recently emigrated from Honduras and presented with a five-day history of sudden onset decreased vision in her right eye, pain with extraocular movements, fevers, and a 3-day history of right upper and lower extremity weakness and numbness. On exam, she was afebrile, and mental status was normal. She had no light perception in the right eye, a right relative afferent pupillary defect, right lower facial weakness, 4/5 strength of proximal and distal right upper and lower extremities, and decreased sensation in the right face, arm, and leg. - Case Report
Conjunctival Kaposi’s sarcoma with orbital extension in an HIV-negative man
Canadian Journal of OphthalmologyVol. 53Issue 3e111–e113Published online: November 30, 2017- Jacqueline Coblentz
- Jea Young Park
- Gerardo Discepola
- Bryan Arthurs
- Miguel Burnier
Cited in Scopus: 3Kaposi’s sarcoma (KS) is a vascular tumour whose development requires infection by human herpesvirus 8 (HHV-8). Although most commonly found in immunosuppressed patients, such as those AIDS, in the United States, classic KS is often found in older-aged men of European or Mediterranean ancestry without immunosuppression. Involvement of the skin of one’s extremities in classic KS is typically more common than that of viscera or mucocutaneous surfaces. - Case Report
Unilateral transient vision loss associated with an opacified Onodi cell
Canadian Journal of OphthalmologyVol. 53Issue 3e117–e120Published online: November 24, 2017- Thomas A. Vo
- Amy Patel
- Chantal J. Boisvert
Cited in Scopus: 0An Onodi cell, also known as a sphenoethmoidal air cell, is a posterior ethmoidal air cell that has pneumatized laterally and rarely superiorly to the sphenoid sinus and is in close approximation to the optic nerve.1 When drainage of the cell is obstructed, visual disturbances can occur by physical compression, inflammation, or a combination of the 2. Nonetheless, optic neuropathy secondary to an isolated opacified Onodi cell is rare.2–4 Herein, we report a case of episodes of unilateral, transient, and painless vision loss caused by an opacified Onodi cell secondary to a focal sinusitis. - Case Report
Unusual ocular presentation in a patient with lichen planus
Canadian Journal of OphthalmologyVol. 53Issue 3e122–e124Published online: November 23, 2017- Samir S. Shoughy
Cited in Scopus: 3Lichen planus is a relatively common mucocutaneous disorder of unknown etiology that is thought to be immunologically mediated. It is a chronic disorder characterized by periods of exacerbation and remission. Lichen planus has variable clinical manifestations, including the skin, oral mucosa, genital mucosa, nails, and scalp. The characteristic lesions have a well-established clinical appearance and histological features that help in establishing the diagnosis.1 Ocular involvement may occur in patients with lichen planus. - Case Report
Mydriasis due to Opcon-A: An indication to avoid pharmacologic testing for anisocoria
Canadian Journal of OphthalmologyVol. 53Issue 1e6–e7Published online: November 8, 2017- Austin S. Nakatsuka
- Hilary A. Beaver
- Andrew G. Lee
Cited in Scopus: 4A 35-year-old woman presented to the Emergency Department with an acute, painless, dilated left pupil. Her medical history was notable for myopia and truncal herpes zoster infection that had completely resolved 2 years ago. Ocular history was significant for bilateral contact lens wear, and her preferred wetting and cleaning solution was Opcon-A (naphazoline and pheniramine). Her surgical, social, and family history and a complete review of systems were unremarkable. On examination, the visual acuity was 20/20 OU. - Case Report
Unilateral isolated foveal hypoplasia
Canadian Journal of OphthalmologyVol. 53Issue 3e107–e109Published online: October 31, 2017- Munir M. Iqbal
- Inas Makar
Cited in Scopus: 3A 9-year-old male was referred to the Pediatric Ophthalmology service for a suspected epiretinal membrane at the left macula. The patient was asymptomatic. His ocular, systemic medical, birth, and developmental history were all noncontributory, and he was not on any prescription medication. - Case Report
Conjunctival-limbal allografts in graft-versus-host disease using same HLA-identical bone marrow transplantation donor
Canadian Journal of OphthalmologyVol. 53Issue 3e120–e122Published online: October 26, 2017- Albert Y. Cheung
- Brad M. Genereux
- Nicholas J. Auteri
- Enrica Sarnicola
- Amit Govil
- Edward J. Holland
Cited in Scopus: 5Hematopoietic stem cell transplantation (HSCT) allows for the transplantation of multipotent hematopoietic stem cells for treatment of hematologic, immunologic, metabolic, and neoplastic diseases. Graft-versus-host disease (GVHD) is a unique complication of allogeneic HSCT in which the donor cells mount an immune response against the host cells.1 Ocular GVHD affects 60%–90% of patients with chronic systemic GVHD.2 - Case Report
Bilateral isolated choroidal melanocytosis with isoautofluorescence
Canadian Journal of OphthalmologyVol. 53Issue 3e97–e99Published online: October 26, 2017- Patricia Hrynchak
- Jennifer Hugh
- Tammy Labreche
Cited in Scopus: 1Ocular melanocytosis is a congenital hyperplasia of the melanocytes in the ocular tissues: episclera, iris, ciliary body, and choroid. It is usually unilateral but can be bilateral. It can affect the surrounding eyelids, as in oculodermal melanocytosis, or be isolated to the choroid, which is referred to as isolated choroidal melanocytosis. Isolated choroidal melanocytosis is an uncommon condition that has been reported unilaterally in a number of cases,1,2 but bilaterally in only 5 other cases in the literature. - Case Report
Late-onset Leber hereditary optic neuropathy presenting after intraocular surgery
Canadian Journal of OphthalmologyVol. 53Issue 3e115–e117Published online: October 25, 2017- Panagiotis I. Sergouniotis
- Anne Fiona Spencer
- Mandagere Vishwanath
- Fion Bremner
- Alec Ansons
Cited in Scopus: 2Leber hereditary optic neuropathy (LHON) is a retinal ganglion cell degeneration characterized by bilateral, typically sequential, acute/subacute central visual loss. This maternally inherited condition arises from point mitochondrial DNA (mtDNA) mutations, and more than 90% of affected individuals harbour 1 of 3 primary mtDNA variants, m.11778G>A, m.14484T>C, or m.3460G>A.1 Intriguingly, (i) the majority of subjects harbouring mtDNA mutations do not develop visual symptoms, (ii) a striking number of LHON patients have no family history, and (iii) there is significant male predominance (male:female, ~3:1). - Case Report
Mantle cell lymphoma: conjunctival mass in a female patient
Canadian Journal of OphthalmologyVol. 53Issue 3e109–e111Published online: October 24, 2017- Xinxin Zhang
- Kathleen B. Gordon
- Renzo A. Zaldivar
- Lamise Z. Rajjoub
Cited in Scopus: 2Mantle cell lymphoma (MCL) is a rare neoplasm in the ocular adnexa, accounting for 3%–5% of conjunctival B-cell non-Hodgkin lymphomas (NHL).1,2 Conjunctival MCL typically presents in male patients in the eighth decade and is often advanced at the time of presentation.3 Treatment typically consists of chemotherapy or radiation, although the prognosis is poor.4 The authors present a rare case of conjunctival MCL in a female patient. Collection and evaluation of protected patient health information complied with the Health Insurance Portability and Accountability Act. - Case Report
Unilateral retinitis pigmentosa: clinical and electrophysiological diagnosis
Canadian Journal of OphthalmologyVol. 53Issue 3e94–e97Published online: September 25, 2017- Pritam Bawankar
- Hemalata Deka
- Manabjyoti Barman
- Harsha Bhattacharjee
- Ronel Soibam
Cited in Scopus: 3Retinitis pigmentosa (RP) is a group of hereditary disorders characterized by gradual atrophy and cell death of the photoreceptors and adjacent cell layers of the retina, the common feature of which is progressive deterioration in vision. Initial presenting symptoms of the disease include night blindness, with gradual deterioration of the light-sensitive cells of the retina, causing diminution of vision in daylight in the later stages. Presentation is bilateral and symmetrical. - Case Report
Transscleral fixation of a toric intraocular lens by a slipable suture technique
Canadian Journal of OphthalmologyVol. 53Issue 1e29–e32Published online: August 29, 2017- Jong Hwa Jun
- Seung Pil Bang
Cited in Scopus: 0In keratoplasty, astigmatic correction is crucial for achieving a favourable visual outcome. Several procedures have been introduced for astigmatic correction, including astigmatic keratotomy,1 wedge resection,2 and excimer laser refractive surgery.3 Each of these procedures have limitations, including unpredictable refractive outcomes, technical difficulty, expenses, and potential complications.4 - Case Report
Bilateral simultaneous artificial iris implantation for post-traumatic aniridia: a case report
Canadian Journal of OphthalmologyVol. 53Issue 1e24–e27Published online: August 28, 2017- Matteo Forlini
- Purva Date
- Barbara Gruber
- Cesare Forlini
Cited in Scopus: 2A blunt ocular trauma may lead to sequelae of aniridia and aphakia. Such presentations may need complex reconstructive surgery. Aniridic patients frequently experience symptoms of decreased visual acuity, diplopia, glare, photophobia, and cosmetic discrepancy. A reconstructive procedure may prove to be challenging when there is loss of capsular support or when minimal iris remnant is present. Oltra et al.1 reported one case of bilateral traumatic aniridia for which coloured contact lenses were offered because patient was asymptomatic. - Case Report
Clinical evaluation of a novel surgical technique (large cross incision) for conjunctival cysts
Canadian Journal of OphthalmologyVol. 53Issue 1e36–e39Published online: August 24, 2017- Tsubasa Nishino
- Akira Kobayashi
- Natsuko Mori
- Toshinori Masaki
- Hideaki Yokogawa
- Kazuhisa Sugiyama
Cited in Scopus: 2An acquired conjunctival cyst may occur spontaneously or after ocular surgery or trauma.1 Chief complaints are foreign-body sensation or cosmetic issues. Although simple needle aspiration might be an easy choice for the treatment of conjunctival cysts, such an approach may be associated with frequent recurrence of the cysts. Typically, a simple resection can resolve the problem; however, incomplete resection may also result in recurrence of the lesion. Moreover, identification of the cyst margin can be difficult because of poor visualization of the cyst capsule. - Case Report
Choroidal metastasis arising from esophageal adenocarcinoma
Canadian Journal of OphthalmologyVol. 53Issue 1e16–e18Published online: August 22, 2017- Maxwell G. Su
- Brian P. Schallenberg
- Michael A. Magee
Cited in Scopus: 0The majority of choroidal metastasis in the eye arises from primary tumours of the breast, lung, prostate, and gastrointestinal tract primary sites but rarely from the esophagus.1–4 Recently, a few cases have been reported that may coincide with the increasing incidence of Barrett’s esophagus and associated esophageal adenocarcinoma.1,2,5 We present a case of esophageal adenocarcinoma that initially presented with signs and symptoms of choroidal metastasis. - Case Report
Orbital metastatic small cell carcinoma of the pancreas with optic nerve compression
Canadian Journal of OphthalmologyVol. 53Issue 1e22–e24Published online: August 7, 2017- Andrew J. Rong
- Catherine J. Choi
- Mark P. Ghassibi
- Sander R. Dubovy
- Thomas E. Johnson
Cited in Scopus: 1Small-cell carcinoma accounts for 18%–20% of all primary lung malignancies but has also been described as arising from the bladder, prostate, stomach, colon, and pancreas.1 Small-cell cancer of the pancreas (SCCP) is an extremely rare malignancy and represents only 0.2%–1% of all pancreatic malignancies.1,2 Here, we describe a unique case of an SCCP presenting as a metastatic lesion to an extraocular muscle causing optic nerve compression. - Case Report
Structural and functional degeneration of retinal nerves in sibling carriers of a Leber’s hereditary optic neuropathy mutation
Canadian Journal of OphthalmologyVol. 53Issue 1e1–e4Published online: August 4, 2017- Richard A. Manfready
- Thomas R. Hedges III
- Carlos E. Mendoza-Santiesteban
Cited in Scopus: 0Leber’s hereditary optic neuropathy (LHON)1 presents with painless bilateral or sequential vision loss caused by degeneration of the papillomacular retinal nerve fibre bundle.2 Optical coherence tomography (OCT) has demonstrated thickening of the retinal nerve fibre layer (RNFL) before and during visual decline, followed by long-term axonal degeneration.3–5 Unaffected male carriers of LHON mutations may experience mild temporal RNFL swelling.4 OCT can further detect ganglion cell complex (GCC) degeneration during disease and preceding symptom onset. - Case Report
Photodynamic therapy for choroidal carcinoid metastasis
Canadian Journal of OphthalmologyVol. 53Issue 1e13–e16Published online: August 3, 2017- Chia-Kai Chu
- Jaafar El-Annan
Cited in Scopus: 7Carcinoid tumours are derived from highly differentiated neuroendocrine cells that often produce biogenic amines or polypeptide hormones. They arise from various primary sites along the gastrointestinal, bronchopulmonary, and urogenital tracts and metastasize to the lymph node, liver, or bone, and only rarely to the eye and orbit. Uveal metastasis is the most common intraocular malignancy and mostly arises from breast cancer in women and lung cancer in men. Uveal metastasis from carcinoid tumours constitutes only 2.2% of all uveal metastasis. - Case Report
Added value of newer optical coherence tomography technologies in hyperphosphatemic familial tumoural calcinosis
Canadian Journal of OphthalmologyVol. 53Issue 1e8–e10Published online: August 3, 2017- Ane Pérez-Sarriegui
- Victoria De Juan
- Francisco J. Muñoz-Negrete
- Gema Rebolleda
Cited in Scopus: 1In contrast to dystrophic calcification seen in several rare genetic disorders, such as pseudoxanthoma elasticum, generalized arterial calcification of infancy, and Keutel syndrome, hyperphosphatemic familial tumoural calcinosis (HFTC) is a rare disorder of phosphate metabolism characterized by hyperphosphatemia and primary ectopic or metastatic calcifications in various locations.1 - Case Report
Case of Ab Interno Trabeculectomy in Juvenile Open-angle Glaucoma with 5-year Follow-up
Canadian Journal of OphthalmologyVol. 53Issue 1e39–e41Published online: July 20, 2017- Samir Nazarali
- Paul Murphy
- Karim F. Damji
Cited in Scopus: 2Juvenile open-angle glaucoma (JOAG) is a subset of primary open-angle glaucoma (POAG) affecting those between 3 and 40 years of age and often with a more progressive course compared to POAG.1,2 Transmission is typically autosomal dominant with mutations identified in the myocilin (MYOC) and CYP1B1 genes.2 - Case Report
Deep anterior lamellar keratoplasty for an intrastromal epithelial corneal cyst: a case report
Canadian Journal of OphthalmologyVol. 53Issue 1e33–e36Published online: July 20, 2017- Aipeng Li
- Yingnan Zhang
- Zhiqiang Pan
Cited in Scopus: 2Corneal cysts, usually caused by the displacement of epithelium into the substance of the cornea, were first described in 1853.1 Congenital or traumatic factors may contribute to the formation of corneal cysts. - Case Report
Management of positive dysphotopsia in a patient with prior refractive surgery
Canadian Journal of OphthalmologyVol. 53Issue 1e27–e29Published online: July 20, 2017- Ayushi Chandramani
- Kamran M. Riaz
Cited in Scopus: 2Dysphotopsias are bothersome visual phenomena experienced by patients after cataract surgery (CS). Positive dysphotopsias (PD) appear as light-related artefacts in various forms, whereas negative dysphotopsias are usually a temporal darkness or shadow in the visual field.1 - Case Report
Implantation pearl cyst after uncomplicated clear cornea phacoemulsification mimicking an iris tumour
Canadian Journal of OphthalmologyVol. 53Issue 1e10–e13Published online: July 20, 2017- Sara Vaz-Pereira
- Gabriella De Salvo
- Lamis Al Harby
- Caroline Thaung
- Mandeep S. Sagoo
Cited in Scopus: 1Epithelial downgrowth (ED) is a serious, although rare, complication of ocular surgery and trauma that can result in irreversible vision loss.1–6 In the ocular surgery group, cataract surgery, especially in the extracapsular era, accounted for 86% of cases1 related to vitreous loss, persistent hypotony, capsule rupture, multiple surgeries, delayed wound healing, wound fistulas, and iris incarceration. According to the literature, 82% of cases presented within the first year after intraocular surgery1,3 with retrocorneal membrane (48%), painful glaucoma (32%), positive Seidel test (24%), corneal edema (22%), hypotony (17%), painless glaucoma (14%), iritis (11%), and iris cyst (8%). - Case Report
Progressive optic nerve glioma: orbital biopsy technique using a surgical navigation system
Canadian Journal of OphthalmologyVol. 53Issue 1e18–e22Published online: June 26, 2017- Ahsen Hussain
- Michael Wan
- Dan DeAngelis
Cited in Scopus: 0An 11-year-old male child presented with worsening vision in his left eye. Examination and imaging revealed a left optic nerve tumour causing mass effect and optic neuropathy, without systemic evidence of neurofibromatosis. In view of the significant risk to visual acuity, a biopsy was deferred and chemotherapy was commenced. After initial stability, continued visual decline necessitated incisional biopsy. Surgical navigation was used to facilitate minimal access surgery avoiding bone removal. The system also precluded biopsy of cystic parts of the tumour, allowing successful intraoperative frozen-section confirmation of lesional tissue. - Case Report
A rare case of bilateral ocular neuromyotonia
Canadian Journal of OphthalmologyVol. 53Issue 1e4–e6Published online: June 24, 2017- Zaria Christine Ali
- Hasan Anzar Usmani
- Alec Ansons
Cited in Scopus: 2Unilateral ocular neuromyotonia (ONM) is a rare entity, and bilateral ONM even more so, with and only 1 case having been reported previously in the literature. We present a rare case of bilateral ocular neuromyotonia whose course of treatment was complicated by side effects of carbamazepine. - Case Report
Mooren’s ulcerative keratitis after systemic pegylated interferon alpha2a in chronic hepatitis C
Canadian Journal of OphthalmologyVol. 52Issue 5e163–e167Published online: June 13, 2017- Joon Hyung Yeo
- Kyoung Woo Kim
- Jae Chan Kim
Cited in Scopus: 3Interferon alpha (IFNα) is a subgroup of the IFN family that is involved in activation of immune responses against viral infection. IFNα2 is secreted by virus-infected cells and inhibits other cells from further infection. IFNα2 has been widely used to manage hepatitis C and multiple sclerosis.1 Although ocular complications with IFN administration occur in less than 1% of patients, they include retinal hemorrhage, cotton wool spots, cystoid macular edema, ischemic optic neuropathy, subconjunctival hemorrhage, dry eye, and Sjögren’s syndrome. - Case Report
Ethambutol optic neuropathy associated with enhancement at the optic chiasm
Canadian Journal of OphthalmologyVol. 52Issue 5e178–e181Published online: May 19, 2017- Patricia G. Lu
- Nathan H. Kung
- Gregory P. Van Stavern
Cited in Scopus: 7A 71-year-old woman was diagnosed with pulmonary Mycobacterium avium complex in 2006 and received multidrug treatment with ethambutol for 18 months between 2008 and 2009, with no ocular symptoms. Because of a progression in pulmonary nodules, ethambutol was restarted in 2015 at a total daily dose of 19 mg/kg along with rifampin and clarithromycin. - Case Report
Cerebellopontine angle astrocytoma producing Bruns nystagmus mimicking vestibular schwannoma
Canadian Journal of OphthalmologyVol. 52Issue 5e181–e182Published online: May 16, 2017- Brian S. Park
- Stacy V. Smith
- Ama Sadaka
- Andrew G. Lee
Cited in Scopus: 1Cerebellopontine angle (CPA) extra-axial lesions (e.g., classically the vestibular schwannoma) may cause a characteristic neuro-ophthalmologic sign known as the Bruns nystagmus, a gaze-evoked horizontal nystagmus when looking away from the lesion and a gaze-paretic type nystagmus when looking toward the lesion. In contrast, intra-axial exophytic CPA astrocytomas are rare and, to our knowledge, have not been reported in the English-language ophthalmic literature previously as a cause of Bruns nystagmus. - Case Report
Childhood glaucoma in neonatal Marfan syndrome resulting from a novel FBN1 deletion
Canadian Journal of OphthalmologyVol. 52Issue 5e171–e173Published online: May 11, 2017- Samir Nazarali
- Safia A. Nazarali
- Angela Antoniuk
- Mark Greve
- Karim F. Damji
Cited in Scopus: 4Marfan syndrome (MFS) is an autosomal dominant genetic disorder of the connective tissue. The majority of MFS cases involve mutations in the FBN1 gene encoding the protein fibrillin-1. Fibrillin-1 is a protein found in the extracellular matrix that is incorporated into the final structure of microfibrils.1 In 25% of cases, the disorder occurs sporadically.2 The most common clinical manifestations resulting from MFS are musculoskeletal, cardiovascular, and ophthalmic. Patients with MFS often present with tall stature, arachnodactyly, and scoliosis, but the severity of the disease varies. - Case Report
Subconjunctival injection of bevacizumab for recurrent conjunctival papilloma: a case report
Canadian Journal of OphthalmologyVol. 52Issue 5e156–e159Published online: May 10, 2017- Chia-Yi Lee
- Hung-Chi Chen
- Yaa-Jyuhn James Meir
- David Hui-Kang Ma
- Wei-Chi Wu
Cited in Scopus: 6Conjunctival papilloma is an acquired benign neoplasm of the conjunctiva and is caused by human papillomavirus, which mostly develops in middle-aged males and often appears as sessile or pedunculated lesions.1–3. The recurrence of conjunctival papilloma is common and has a recurrence rate of >10%.1–3 The conventional therapeutic options include surgical excision and cryotherapy for eradication, but usually conjunctival papilloma recurs, and repeated excisions may lead to ocular surface damage.4,5 Topical interferon, topical mitomycin C, and oral cimetidine are therefore used as adjuvant treatments. - Case Report
Persistent pediatric primary canaliculitis associated with congenital lacrimal fistula
Canadian Journal of OphthalmologyVol. 52Issue 5e161–e163Published online: May 10, 2017- Jingwen Ding
- Hua Sun
- Dongmei Li
Cited in Scopus: 5Primary canaliculitis is an uncommon infection of the lacrimal canaliculus. It is frequently misdiagnosed as chronic conjunctivitis or dacryocystitis, which results in delayed or improper treatment. The challenge of treatment is to eradicate the causative pathogens on the basis of maintaining the canalicular patency.1 We present a refractory case of primary upper canaliculitis associated with congenital lacrimal fistula. - Case Report
Eye drop safety seal causing ocular irritation following cataract and vitrectomy surgery
Canadian Journal of OphthalmologyVol. 52Issue 5e167–e169Published online: May 6, 2017- Jonathan S. Chang
- Danielle Trief
Cited in Scopus: 0Applying medication directly to the eye was first reported in ancient cultures, and modern pharmacotherapy with eye drops is likely to have begun when pilocarpine and atropine were isolated as therapeutics in the late 19th century.1 Since then, eye drops have been used as a primary delivery method for many classes of medications. Just as with oral medications,2 patients have difficulty remembering the names, frequencies, and dosages of the eye drops they are taking.3 In addition, effective administration of drops can be difficult, especially for patients with problems with dexterity or low vision. - Case Report
Intraretinal macular hemorrhage due to high-power handheld blue laser
Canadian Journal of OphthalmologyVol. 52Issue 5e193–e195Published online: May 3, 2017- Sulaiman M. Alsulaiman
- Maher F. Al-Marwani Al-Juhani
- Nicola G. Ghazi
Cited in Scopus: 2We recently reported various forms of maculopathies related to high-power handheld blue laser injury. This included subhyaloid/subinternal limiting membrane hemorrhage, epiretinal membrane, foveal schisis-like changes, outer retinal disruption, and full-thickness macular hole.1 Here we present a new manifestation of blue laser–induced maculopathy. - Case Report
Optic nerve hypoplasia in a patient with a de novo KIF1A heterozygous mutation
Canadian Journal of OphthalmologyVol. 52Issue 5e169–e171Published online: May 3, 2017- Lina Raffa
- Marie-Pierre Matton
- Jacques Michaud
- Elsa Rossignol
- Jean-Claude Decarie
- Luis H. Ospina
Cited in Scopus: 9Kinesin superfamily proteins (KIFs) are molecular motors that use microtubules as a “rail” to transport membrane vesicles and organelles, protein complexes, and messenger RNAs (mRNAs). KIF1A drives the microtubule plus end toward the axon terminal, which is most prominent in polarized cells, including neurons, and is fundamental for neuronal function and survival. Kinesins have long been implicated in the pathogenesis of axonal neuropathies. We report a child with a de novo KIF1A gene mutation who was found to have bilateral optic nerve hypoplasia and atrophy. - Case Report
Case series: Merkel cell carcinoma of the eyelid
Canadian Journal of OphthalmologyVol. 52Issue 5e182–e185Published online: April 21, 2017- Cristina Bostan
- Mariana Botelho Dias de Souza
- Pablo Zoroquiain
- Luiz Augusto Guimarães de Souza
- Miguel N. Burnier Jr.
Cited in Scopus: 2Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine malignancy hypothetically derived from a precursor common to keratinocytes and Merkel cells.1 Only 5% to 10% of MCCs involve the eyelids and the periocular region,2 of which fewer than 100 cases have been reported to date.3,4 Here, we present 3 new patients with MCC of the eyelid and discuss diagnostic considerations. - Case Report
Chandelier scleral buckling for retinal detachment in Stevens-Johnson syndrome
Canadian Journal of OphthalmologyVol. 52Issue 5e190–e192Published online: April 20, 2017- Charu Gupta
- Daraius Shroff
- Deepender Chauhan
- Indranil Saha
- Cyrus Shroff
Cited in Scopus: 0A 40-year-old uniocular man presented with a 2-week history of a sudden decrease in vision in the left eye. Visual acuity was light perception with inaccurate projection of rays OD and counting fingers at 1 m, N48 OS. The patient had a history of loss of vision in the right eye 30 years previously because of postvaricella (chicken pox) Stevens-Johnson syndrome. The right showed a total leucomatous corneal opacity (Fig. 1). The left eye showed a vascularized corneal scar involving the nasal two-thirds of cornea, with superficial punctate keratitis. - Case Report
Ciliochoroidal detachment following pure sulfur hexafluoride injection in Descemet stripping automated endothelial keratoplasty
Canadian Journal of OphthalmologyVol. 52Issue 5e159–e161Published online: April 20, 2017- José Antonio Gegúndez-Fernández
- José Ignacio Fernández-Vigo
- David Díaz-Valle
- Ricardo Cuiña-Sardiña
- José Manuel Benítez-del-Castillo
Cited in Scopus: 0Descemet stripping automated endothelial keratoplasty (DSAEK) is an effective and safe treatment for Fuchs dystrophy and pseudophakic corneal edema, among other ocular conditions.1–3 The most common complication of this surgical procedure is graft detachment, which may be effectively resolved in most cases by rebubbling with air or gas (or both) to reposition the graft.1–3 - Case Report
Haller cells: A risk factor for spontaneous orbital floor fracture?
Canadian Journal of OphthalmologyVol. 52Issue 5e185–e188Published online: April 18, 2017- Ahsen Hussain
- James Oestreicher
- Navdeep Nijhawan
Cited in Scopus: 2Orbital floor fractures most commonly occur as a consequence of trauma through either buckling or hydraulic forces acting on the orbit. Spontaneous orbital floor fractures have been described in the literature usually in the setting of thyroid eye disease (TED). We present the case of a patient with a history of a spontaneous floor fracture associated with anteriorly displaced ethmoid air cells. We propose a pneumatic mechanism of spontaneous floor fracture in patients with Haller cells. - Case Report
Immunoglobulin G4–related dacryocystitis
Canadian Journal of OphthalmologyVol. 52Issue 5e188–e190Published online: April 18, 2017- Yasuhiro Takahashi
- Emiko Takahashi
- Kunihiro Nishimura
- Hirohiko Kakizaki
Cited in Scopus: 6Immunoglobulin G4 (IgG4)–related dacryocystitis is a rare condition characterized by elevated serum IgG4 levels and IgG4-positive lymphoplasmacytic infiltration in the lacrimal sac.1 In the periocular region, IgG4-positive lymphoplasmacyte infiltration commonly occurs in the lacrimal gland, extraocular muscles, orbital soft tissues, and the infraorbital nerve.1 Clinicopathologic characteristics of IgG4-related dacryocystitis are not fully understood. Herein, we report the case of a patient with IgG4-related dacryocystitis. - Case Report
Treatment of choice for patients with EGFR mutation–positive non-small cell lung carcinoma presenting with choroidal metastases: radiotherapy or TKIs?
Canadian Journal of OphthalmologyVol. 52Issue 1e22–e25Published in issue: February, 2017- David Maskell
- Konstantinos Geropantas
- Michael Kouroupis
- Andrew Glenn
- Thankamma Ajithkumar
Cited in Scopus: 11It is not uncommon for patients with non-small cell lung cancer (NSCLC) to develop choroidal metastases (CM). External beam radiotherapy (EBRT) has traditionally been considered the treatment of choice for CM as it offers high response rates and quick relief of symptoms. However, new targeted treatments can offer an effective, alternative treatment strategy for patients harbouring specific genetic abnormalities. - Case Report
Hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome
Canadian Journal of OphthalmologyVol. 52Issue 1e41–e44Published online: January 5, 2017- Yanna Cao
- Xingping Zhao
- Junhui Yi
- Renhong Tang
- Shaobo Lei
Cited in Scopus: 3Hantavirus infection of the retina has not been reported in the literature. We describe the first case of presumed hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome (HFRS), which presented with typical symptoms of HFRS and subsequent vision loss because of posterior necrotizing retinitis. - Correspondence
Corneal etching in femtosecond laser-assisted cataract surgery
Canadian Journal of OphthalmologyVol. 52Issue 1e15–e18Published online: January 4, 2017- Giancarlo A. Garcia
- Jack J. Tian
- Khalil Ghasemi Falavarjani
- Rustum Karanjia
- Kenneth L. Lu
Cited in Scopus: 0Femtosecond laser technology can be used in cataract surgery to perform the capsulotomy, lens fragmentation, and corneal incisions. Compared to traditional cataract surgery, femtosecond laser-assisted cataract surgery (FLACS) can offer potential advantages such as enhanced intraocular lens centration1,2 and decreased phacoemulsification power.3,4 However, the potential for increased utility and safety over conventional techniques has not been definitively established.5,6 Though FLACS is generally a safe procedure, complications can include suction loss, anterior capsule tears or tags, posterior capsule rupture, dropped nuclei, or vitreous loss. - Case Report
Eyelid fungal infections are rare, and often associated with predisposing factors. We present the case of a child with an ulcerated lesion of fungal etiology on the eyelid.
Canadian Journal of OphthalmologyVol. 52Issue 1e28–e29Published online: January 3, 2017- Roshmi Gupta
- Parvathi Hari
- Venkataramana Anandula
Cited in Scopus: 0An 8-year-old male presented with right periocular swelling, redness, pain, watering, and sloughing of skin over the lower eyelid of 3 weeks’ duration. As per his parents, the child had a history of probing for right congenital nasolacrimal duct obstruction conducted elsewhere, immediately after which the signs and symptoms occurred. However, no further details were available regarding the procedure. He had received intravenous cephalosporins elsewhere for the lesion but had showed no improvement. - Case Report
Synergistic innervational downshoot: a distinct vertical dysinnervation pattern and its unique management
Canadian Journal of OphthalmologyVol. 52Issue 1e31–e38Published online: November 18, 2016- Pradeep Sharma
- Shweta Chaurasia
- Abhijit Rasal
- Dewang Angmo
Cited in Scopus: 8Synergistic divergence (SD), first described by Barany et al.1 and later studied electromyographically by Wilcox et al.,2 is a rare but well-established horizontal congenital cranial dysinnervation disorder (CCDD).3–12 In addition to unusual synergism affecting horizontal muscles, there are many reports in the literature regarding anomalous vertical synergism.7,10–12 In 1996, Weinacht et al. described synergistic innervations between lateral rectus (LR) and ipsilateral vertical acting muscles under vertical Duane’s retraction syndrome. - Case Report
Microcystic macular edema in a case of tobacco–alcohol optic neuropathy
Canadian Journal of OphthalmologyVol. 52Issue 1e19–e22Published online: November 17, 2016- Shreya Haldar
- Raj Mukherjee
- John Elston
Cited in Scopus: 5Microcystic macula edema (MME) is characterized by hyporeflective spaces limited to the inner nuclear layer of the parafoveal region.1 It is distinguished by foveal sparing. MME is believed to be caused by retrograde Müller cell degeneration, although trans-synaptic degeneration and vitreous traction may be involved.2,3 First described in multiple sclerosis, MME is seen in various inflammatory and noninflammatory optic neuropathies as well as other retinal pathologies (Table 1).4,5 Diagnosis is made on the basis of optical coherence tomography (OCT) demonstrating characteristic changes in the parafoveal region. - Case Report
Atypical transient subretinal exudation following photodynamic therapy for chronic central serous retinopathy: a case report
Canadian Journal of OphthalmologyVol. 52Issue 1e38–e41Published online: November 17, 2016- Ahmad Al-Awadi
- Efrem D. Mandelcorn
- Sohel Somani
Cited in Scopus: 6Central serous retinopathy (CSR) is a common ocular disease of young and middle-aged adults that affects men more than women. It manifests as the accumulation of central subretinal fluid (SRF) with or without the presence of retinal pigment epithelial detachment (RPED) and is often associated with reduced visual acuity (VA) or metamorphopsia.1 Most cases of idiopathic CSR resolve spontaneously; however, chronic cases in which the SRF persists longer than 3 months may require treatment.2 In cases of CSR with a focal leak, retinal laser photocoagulation may be an appropriate treatment option to accelerate the resorption of SRF and improve VA.