Paracentral acute middle maculopathy after meningococcal vaccination in a young femaleParacentral acute middle maculopathy (PAMM) is an uncommon clinical presentation of a retinal ischemic insult within the deep capillary plexus (DCP) of the retina. This results in a characteristic scotoma corresponding to the area of ischemia and area of abnormal hyper-reflectivity of the inner nuclear layer (INL) on optical coherence tomography (OCT).1 Previously there have been very few reports of PAMM resulting from a vaccination. There have been no cases of PAMM following the administration of a meningococcal vaccine, and to our knowledge this case represents the youngest recorded case of vaccine-associated PAMM in an otherwise healthy child.
Wet age-related macular degeneration refractory to aflibercept but responsive to systemic everolimusA 69-year-old Caucasian woman with a history of metastatic breast cancer had been receiving injections of aflibercept every 4–8 weeks for wet age-related macular degeneration in her right eye for the past 4 years. Despite the regular frequency of the aflibercept injections, her optical coherence tomography had always demonstrated significant levels of intraretinal fluid (Fig. 1). It was decided in the past to maintain her schedule of aflibercept in order to maintain her baseline level of vision of 20/60.