The Splendore-Hoeppli phenomenon is considered a rare and distinct local mucocutaneous inflammatory reaction to antigens of a vast variety of infectious agents including fungi, bacteria, and parasites, and to some foreign material such as silk sutures.1 Hypereosinophilic syndrome and allergic conjunctival granulomas are noninfectious disorders that may also be associated with Splendore-Hoeppli phenomenon.1,2 In most conjunctival lesions, however, the definitive causative agent cannot be identified.
The Splendore-Hoeppli phenomenon is considered a rare and distinct local mucocutaneous inflammatory reaction to antigens of a vast variety of infectious agents including fungi, bacteria, and parasites, and to some foreign material such as silk sutures.1 Hypereosinophilic syndrome and allergic conjunctival granulomas are noninfectious disorders that may also be associated with Splendore-Hoeppli phenomenon.1,2 In most conjunctival lesions, however, the definitive causative agent cannot be identified.